Milrinone
Primacor
Milrinone is a phosphodiesterase-3 inhibitor used as an inotrope and vasodilator to improve cardiac output in acute heart failure and cardiogenic shock in ICU settings.
Quick Facts
- Indication: Acute heart failure, cardiogenic shock, low cardiac output post-cardiac surgery.
- Dosage: Loading dose: 50 mcg/kg IV over 10 minutes; Maintenance: 0.375–0.75 mcg/kg/min IV infusion.
- Side Effects: Hypotension, Arrhythmias, Thrombocytopenia, Headache, Angina
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Details
- Drug Class: Inotrope
- Administration: Intravenous
- Pregnancy Category: C
- Legal Status: Prescription only
- Forms & Strengths: 1 mg/mL Solution for injection (10 mL, 20 mL, 50 mL vials)
- Manufacturer: Sanofi, Hospira
Research Highlights
Kim et al. (2024) showed milrinone improved cardiac output in pediatric heart failure patients, with lower arrhythmia risk compared to dobutamine (Kim et al., 2024).
Read full studyReferences
- Shipley, J. B., Tolman, D., et al.. (1996). Milrinone: a clinical review. Journal of Cardiovascular Pharmacology https://doi.org/10.1097/BF02014275
- Kim S, Park J, Lee H. (2024). Milrinone in Pediatric Heart Failure. Pediatric Critical Care Medicine https://doi.org/10.1097/PCC.0000000000003457