Rocuronium

(Zemuron)

Neuromuscular Blocking Agents & Reversals

Rocuronium is an aminosteroid non-depolarizing NMBA with rapid onset (60-90 sec) and intermediate duration (30-60 min). At higher doses (1.2 mg/kg), it can provide intubating conditions similar to succinylcholine, making it the primary alternative for RSI. Rocuronium is eliminated primarily by the liver (70%), with some renal excretion (30%). The drug has minimal cardiovascular effects and does not trigger malignant hyperthermia. Sugammadex provides rapid and complete reversal of rocuronium at any depth of block. Rocuronium is commonly used for routine intubation and maintenance of paralysis in the OR and ICU.