Vasopressin

(Pitressin)

Cardiovascular Agents

Vasopressin is a synthetic antidiuretic hormone analog that causes vasoconstriction via V1 receptors, used as an adjunct in septic shock and for diabetes insipidus. Unlike catecholamines, its vasoconstrictive effects are preserved in acidotic states. Vasopressin is particularly valuable in refractory vasodilatory shock and reduces norepinephrine requirements. The drug also has antidiuretic effects via V2 receptors at lower doses.